Early-onset food allergy in Alzheimer’s disease is associated with later allergic respiratory disease

Pediatric patients with early atopic dermatitis (AD) who report a food allergy have been associated with subsequent allergic respiratory disease, in which persistence of Alzheimer’s disease has been associated with multiple food allergies.

Pediatric patients with early atopic dermatitis who reported a food allergy were associated with later allergic respiratory disease, according to study results published today in French Journal of Allergy.

Characterized by the development of atopic disorders, the widely held concept called Atopic Marsh explains the pattern in which Alzheimer’s disease develops in children followed later by food allergies, allergic rhinitis, and allergic asthma.

Several prospective birth cohorts have shown an association between early onset of Alzheimer’s disease and the development of allergic rhinitis and asthma at school age, as sensitivity to immunoglobulin E (IgE) may increase the risk of these conditions.

Atopy is defined as a personal and/or familial tendency to produce IgE antibodies and sensitize in response to allergen exposure. The study author explained that the main food allergens in pediatric patients with Alzheimer’s disease include egg whites, cow’s milk, soybeans, wheat and peanuts.

In an effort to further investigate the course of allergic diseases in pediatric patients with early-onset Alzheimer’s disease, a single central retrospective study of data from Diyarbakir Children’s Hospital in Turkey was performed. Patients aged 3–7 years with Alzheimer’s disease in the first 2 years of life and their control counterparts (n = 211) were screened for a diagnosis of wheezing, Alzheimer’s disease, and allergic rhinitis from the hospital database and the Government’s E-Health Service.

The study group included 119 children diagnosed with Alzheimer’s disease aged 0-2 in 2013 (mean [SD] age, 12.1 [7.3] months; 60.5% male; You know? [SD] Serum total IgE level, 157.9 [232.5] kU/L) and 92 children of the control group aged 0–3 months who underwent a screening hearing test in the same year.

Between the two groups, the mean number of serum eosinophils showed significantly higher in the AD group versus the control group (738/mm3 vs 364 / mm3; s <.001). The frequency of at least 3 whistling attacks was significantly higher in the AD group versus the control group for children under two years of age (17.6% vs 4.3%; s = .002), while the frequency of at least one wheezing attack (28.6% vs 29.3%), at least 3 wheezing attacks (15.1% vs 9.8%), and allergic rhinitis (22.7% vs 22.8%) were not significantly different Between AD and control groups in children 3-7 years old.

However, the results further showed that in the AD group, the frequency of at least one wheezing attack (42.6% vs. 19.4%; s = .006), at least 3 beep attacks (25.6% vs. 8.3%; s = .011), allergic rhinitis (38.3% vs. 12.5%); s = .001) were significantly higher in children with a food allergy compared to the subjects without a food allergy.

Although the frequency of persistent AD was not significantly different between those with and without a food allergy (19.1% vs. 23.6%; s = .367), the frequency of persistent AD was significantly higher in children with a food allergy than in children with a single food allergy (33.3% vs 7.7%; s = .032).

The study author concluded, “This study demonstrated that later allergic respiratory disease in children with early-onset Alzheimer’s disease was associated with food allergy regardless of early wheezing, and that persistence of Alzheimer’s disease was associated with multiple food sensitivities.”

reference

Özcan C. The atopic course of children with early atopic dermatitis: a retrospective study. Reverend Fr Allergol. Published online May 31, 2022. doi: 10.1016 / j.reval.2022.04.006

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