Graduated oral feeding challenges show that many sensitive infants can safely eat chicken eggs

05 August 2022
2 minutes to read

Source / Disclosures

Disclosures: Mitomori did not report any relevant financial disclosures. Please see the study for all relevant financial disclosures by other authors.


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Few of the children who are allergic to eggs had to avoid consuming eggs entirely, and most were able to eat a whole scrambled egg after completing their oral eating challenges, according to a letter published in Pediatric sensitive and immunology.

Starting at a low dose, progressive OFCs appear to be safe and effective for introducing eggs and determining safe ingestion doses for infants, Masatoshi MitomoriAnd the of the Department of Pediatrics at Sagamihara National Hospital of the National Hospital Organization in Kanagawa, Japan, and colleagues wrote in the study. Although the data have shown that progressive OFCs are safe and effective for patients with suspected egg allergy, previous studies have not evaluated these OFCs among children who have not yet consumed eggs.


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The researchers retrospectively examined 87 infants who had no previous history of egg consumption but were diagnosed with an egg allergy after blood tests revealed egg white IgE (EW-sIgE) levels greater than 0.1 kg.a/ to.

These infants then participated in progressive OFCs.

According to the researchers, 12 (14%) infants failed to take a low-dose OFC of 25 heated eggs, or 250 mg of egg protein. Nine children (12%) failed to take an average dose of the OFC of one-eighth of a heated egg, or 775 mg to 769 mg of egg protein. Eight (12%) children then failed to take a high-dose OFC for half a heated egg, or 3,076 mg to 3,100 mg of egg protein.

Of the 58 infants who passed the high-dose OFC, 32 took the full-dose OFC from a whole scrambled egg with 6591.5 mg of egg protein and 26 were instructed to increase egg consumption at home to one scrambled egg. Two of these 58 infants failed the full dose of OFC.

Overall, 56 of 87 (64%) infants allergic to eggs had no allergic reaction to eggs.

Twelve (14%) of the egg-allergic children needed to continue to avoid egg consumption altogether. Meanwhile, the probability curves indicated that more than half of the egg-sensitive infants would pass a full dose of OFC even with EW-sIgE levels above 100 kU.a/ to.

Six of the infants in the study had EW-sIgE levels in excess of 100 kUa/L, with one also exceeding 100 kUa/ l in the levels of white mucous bodies. Five of these kids managed to eat a whole scrambled egg.

None of the infants who went through either an average dose or a full dose of OFCs had any severe symptoms, but one infant who received intramuscular adrenaline due to vomiting and pallor during a low dose OFC. Also, one infant developed a barking cough while taking a high dose of OFC.

With most of these infants able to eat a whole scrambled egg, even with relatively high levels of EW-sIgE, the researchers concluded that progressive OFCs appear to be beneficial for infants who are allergic to the egg due to the low rate of positive reactions and their ability to clarify thresholds. For safe ingestion.

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